Multi-drug resistance among the Escherichia coli isolated from
suspected cases of septicemia
Shoorashetty Manohar Rudresh1*, Giriyapur Siddappa Ravi2
1*Associate Professor, 2 Professor, Department of Microbiology, ESIC MC PGIMSR & MH, Rajajinagar, Bengaluru, Karnataka
Year : 2021 | Volume : 4 | Issue : 1 | Page : 14 | DOI -10.46319/RJMAHS.2021.v04i01.003
Aim: Bacterial blood stream infections (BSI) are major cause of mortality and morbidity. The Escherichia coli (E. coli) is the common gram-negative bacteria (GNB) causing BSIs. The occurrence of multi-drug resistance among E. coli causing blood stream infections has increased over a decade. Early detection and management of cases will decrease the mortality. Methods: A total of 5000 blood cultures were received from September 2015 to August 2016 from suspected cases of septicemia. The blood culture was done using BactAlert 3D automated system. Any growth was identified by conventional biochemical tests. The antibiotic susceptibility pattern was determined according CLSI guidelines. The ESBL, AmpC and MBL were detected. Results: Among the 248 positive blood cultures, 195 were gram negative bacteria and 53 were gram positive bacteria. A total of 26 E. coli were isolated, accounting for 13.3% of GNB. The E. coli had highest resistance to β-lactam antibiotics (92%) followed by ciprofloxacin (85%) and cotrimoxazole (62%). They showed a good sensitivity to colistin (100%), carbapenems (92%) and amikacin (89%). The extended spectrum β-lactamase (ESBL) production was seen in 65%, AmpC production in 19% and MBL production was seen in 8% of isolates. Conclusion: Increased proportion of E. coli bacteremia was noted compared to previous studies. The occurrence of multi-drug resistance and resistance to 3rd generation cephalosporins limits the treatment options.
Key words: Septicemia, Escherichia coli, Bacteriaemia, multi-drug resistance, Extended spectrum β-lactamase.
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